The effect of wheat germ oil on sperm concentration in carbon tetrachloride-exposed male mice

Background: The bio-protective effects of wheat germ oil (WGO) as an oxidative damages inhibitor anti-oxidant have been attributed to its high vitamin E content. This study was carried out to investigate the effects of WGO on epididymal sperm quantity in male mice exposed to carbon tetrachloride (CCL4).Methods: Forty-eight adult male mice were randomly divided into 6 equal groups (n = 8) including untreated control, CCL4 (50%, 1 mL/kg; IP), CCl4 + WGO (250 mg/kg; PO), CCl4 + WGO (500 mg/kg; PO), WGO (250 mg/kg; PO) and WGO (500 mg/kg; PO). Epididymal sperm count in all experimental groups was evaluated after 28 days.Result: The results showed that CCL4 administration causes remarkable sperm count reduction compared to the control mice. Notably, coadministration of WGO with CCL4 in mice resulted in a significant sperm concentration increase compared to CCL4-treated mice. These findings indicate that WGO can be a potent protective agent against CCL4-induced reproductive damages in mice.Conclusion: WGO improved adverse effects of oxidative stress on sperm concentration

کلیدواژه ها:

Mouse ، Oxidative stress ، Sperm concentration ، Wheat germ oil ، Carbon tetrachloride