Glis2 and Breast cancer

سال انتشار: 1394
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 315

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شناسه ملی سند علمی:

ICBCMED11_260

تاریخ نمایه سازی: 21 اردیبهشت 1397

چکیده مقاله:

Introduction: The GLIS family members are the Krüppel-like zinc finger proteins with transcriptional repression and activation function. Glis2 is one of these family members which its relation revealed with some diseases such as Nephronophthisis (NPHP), an autosomal recessive renal disease, and in non-Down syndrome acute megkaryoblastic leukemia and meningiomas cancers. A microarray analysis in 2014 presents Glis2 as a new gene involved in breast cancer. A study to examine the effects of and changes in gene expression simultaneously for Han Chinese breast cancer showed that the most frequent genomic loci about ER signature located on 8 and 16 chromosomes. One of these genes is Glis2 on 16 chromosome. Result: regarding to the relation of this factor with other cancers and Hedgehog and Wnt/β-catenin signalling pathways-important pathways that involve in both normal and tumor genesis of breast tissue-the possibility of alteration in Glis2 mRNA expression level in breast cancer is. Discussion: Our study suggested a probable relationship between alteration of Glis2 expression and breast cancer that can be proved with techniques such as Real time PCR. Also detection of a probable association between alteration of Glis2 and breast cancers without Her2 and ER/PR receptors might be usefull for prognostic and diagnostic uses or as probable target for treatment of these patients.

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نویسندگان

Minoosh Sadeghi

Shahrekord university