Evolutionary relationship between Arabidopsis thaliana andHomo sapiens Cu/Zn superoxide dismutase genes

Superoxide dismutase has important roles to detoxify reactive oxygen species toxicity in all aerobic organisms. Also it s expression increase under abnormal and stressful conditions. In this research genetics, amino acids and promoter of Cu/Zn Superoxide dismutase for human and Arabidopsis plant analyzed. Raw data collected from NCBI and Uniprot websites. Map viewer results indicated that this gene localized on chromosome 21, it has 5 exons and 4 introns, but in Arabidopsis Cu/Zn SOD exist on chromosome 21 and has 8 introns. Also indicated binding sites and variations and network display of two Cu/Zn SODs with other molecules. Promoter analyses indicated that these genes have some transcription factors such as early responsive to dehydration and ABA-responsive that important to oxidative stress tolerance. MEME analyzed showed that there are important motifs such as GLHGFHVH, GPHFNP and DDLGKGG which conserved under evolution. It seems that this study results can be useful for protein engineering and production of transgenic organisms.

کلیدواژه ها:

Arabidopsis thaliana ، Homo sapiens ، Bioinformatics ، Phylogeny tree ، Cancer ، Evolution ، Superoxide dismutase gene