Biodistribution of I131 Labeled ICD-85 in Normal and Breast Bearing Mice

سال انتشار: 1391
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 499

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شناسه ملی سند علمی:

ICBCMED08_073

تاریخ نمایه سازی: 29 فروردین 1397

چکیده مقاله:

The report from ministry of health in Iran indicate that yearly at least 70000new cases of cancer are registering out of which 30000 are leading to death.Although chemotherapy and radiotherapy in early stages of cancer are able toreduce the mortality rate but their side effects are limited their affectivity incancer treatment. The new peptides isolated from animal’s venom called ICD-85 are proved to inhibit the growth of cancer cells in vitro and in vivo. In thepresent report we tried to find the biodistribution of ICD-85 in healthy andbreast tumor bearing mice. ICD-85 was labeled by I131 and injected to mice.The biodistribution of ICD-85 in various organs at 30 and 45 min. following theI.V injection was determined. Results indicated that the bioaccumulation ofICD-85 within 30 min was above 15% in breast tumor and at 45 min themaximum level of ICD-85 was found in kidney. The rate of accumulation ofICD-85 in tumor versus blood was found to be 295% at 30 min. In conclusionbased on the results obtained, it is clear that at early time following I.V injectionof ICD-85, the maximum bioaccumulation occurs in tumor and later in kidneyand liver.

کلیدواژه ها:

Breast tumor bearing mice ، Biodistribution of ICD-85 ، I131

نویسندگان

Ali Sarzaeem

Department of Venomous Animals and Antivenom Production,Razi Vaccine and Serum Research Institute, Karaj, Iran

Pezhman Shimardi

Department of Venomous Animals and Antivenom Production,Razi Vaccine and Serum Research Institute, Karaj, Iran

Abbas Zare Mirakabadi

Department of Venomous Animals and Antivenom Production,Razi Vaccine and Serum Research Institute, Karaj, Iran