Impact of curcumin on microrna expression in colorectal cancer: asystematic review

Colorectal cancer(CRC) is the second most common cancer in women and the third one in men. Also one of the major cause of morbidity and mortality in the world. However, it’s considered to be curablecancer by modifying dietary habits and other risk factors including obesity, smoking and alcohol consumption. MicroRNAs (miRs) are small RNAs that suppress mRNA translation and interfere in cell proliferation, differentiation, and apoptosis. Bioactive compounds such as curcumin, have a modulating role in the expression of miRs. Curcumin is a polyphenolic compound derived from the turmeric (rhizomes of Curcuma longa). hence in this review, we aimed that show the modulation of miRs by curcumin as a nutritional compound in CRC.We searched PubMed and Google Scholar databases in a wide range by utilizing colorectal cancer or CRC , diet , miR or microRNA and curcumin keywords and combined with AND/OR. final papers that we were checked was 67 numbers.In many papers, miR21 was considered as an oncogenic miR (oncomiR).In one xenograft mouse study, Difluorinated curcumin(CDF), a novel analog of the dietary ingredient curcumin, repress miR21 expression, reduce Akt activity and rescue expression of PTEN(phosphatase and tensin homolog) signaling pathway which it effects on cell differentiation and apoptosis. In some paper miR- 21 suppression, inhibits COX2 that is the cause of NF-kB, PGE2 reduction and suppress angiogenesis and cell proliferation. Additionally, curcumin upregulate miR-34 and downregulate miR-27. In an article proved that miR-34 related with some anti-apoptotic ingredient such as Bcl2 and Akt. Also, downregulation of miR-27 reduce transcription factors, that is lead to apoptosis of colon cancer cells. however, a few studies found no significant association between miR-21 expression and CRC.The contribution of curcumin and miRs have been demonstrated in many papers. hence we should consider miRs in a therapeutic and prognostic aspect in cancers such as CRC.notwithstanding significant evidence, it is needed to evaluate the impact of curcumin on cancer by clinical research

کلیدواژه ها:

Colorectal Cancer ، Cancer Prevention ، Gene and Cancer ، Cell and Cancer ، Cancer Risks ، Nutrition and Cancer ، Cancer Genetics