Role of fabp family in development and pathogenesis of cancers

One of the most important involved pathways in cancer development is fatty-acid signaling pathway. Synthesized lipids as energetic sources are consumed by cancer cells in order to proliferation, growth,survival, invasion and angiogenesis. Fatty acids as signaling compounds regulate metabolic and transcriptional networks, survival pathways and inflammatory responses. Aggregation of fatty acidswith fatty acid binding proteins (FABPs) makes them capable to fatty acid transportation to different cell organelles. FABPs, a group of lipid binding proteins modulate fatty acid metabolism, cell growthand proliferation and cancer development. They may be used as tumor marker in some cancers. FABPs are expressed in most malignancies such as prostate, breast, liver, bladder and lung cancer, and areassociated with the incidence, proliferation, metastasis, invasion of tumors. This review introduces several isoforms of FABPs (FABP1-12) and summarizes their function and their possible roles in cancer development through some proposed mechanisms

کلیدواژه ها:

Cancer Symptoms ، Cancer Diagnosis ، Gene and Cancer ، Cell and Cancer ، Cancer Risks ، Cancer Genetics