Wnt5a: A Key Regulator Of Inflammation
- سال انتشار: 1395
- محل انتشار: دومین سمپوزیوم بین المللی سرطان نسترن
- کد COI اختصاصی: NASTARANCANSER02_045
- زبان مقاله: انگلیسی
- تعداد مشاهده: 441
نویسندگان
Department Of Medical Biochemistry, School Of Medicine, Mashhad University Of Medical Sciences, Mashhad, Iran
Department Of Medical Biochemistry, School Of Medicine, Mashhad University Of Medical Sciences, Mashhad, Iran
Department Of Medical Biochemistry, School Of Medicine, Mashhad University Of Medical Sciences, Mashhad, Iran
Department Of Medical Biochemistry, School Of Medicine, Mashhad University Of Medical Sciences, Mashhad, Iran
چکیده
Wnt proteins are a family of glycoproteins which upon binding to a member of G-protein coupledreceptor, Frizzled (Fz), activates a scaffolding protein Disheveled (Dvl) to elicit their intracellularsignaling functions. Wnt signaling is classified to canonical (βcatenin-dependent) and noncanonical(βcatenin-independent) pathways. Wnt5a, a member of Wnt proteins, is consistently upregulatedby endotoxin (LPS) and interferon (INF)-γ via Toll-like receptor (TLR) activation.Through up-regulation of inflammatory cytokines including IL-1β, IL-6, IL-8, IL-1α and activation ofinflammatory signaling pathways such as nuclear factor-κB (NF-κB) and JNK, Wnt5a elicitsproinflammatory responses in cells. Over the last decades, Wnt5a has been implicated in a varietyof inflammatory diseases including atherosclerosis, obesity, sepsis, rheumatoid arthritis,psoriasis, melanoma, and tuberculosis. The elevated levels of Wnt5a in inflammatory diseasessupport the hypothesis that this protein could be a prognostic marker of inflammation and itssuppression either through inhibition of upstream signaling pathways or through Wnt signalingantagonists is an attractive target for therapeutic intervention in inflammatory disorders.کلیدواژه ها
مقالات مرتبط جدید
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.