Solubility, modeling and thermodynamic properties of budesonide in ethanol – water mixtures from T = (293.2 to 313.2) K

The solubility of budesonide (BDS) in binary mixtures of ethanol and water at 293.2, 298.2, 303.2, 308.2 and 313.2 K was obtained. The trained versions of the van’t Hoff equation, its combined version with log-linear model, Jouyban– Acree model and a combination of van’t Hoff + Jouyban–Acree model were reported to simulate BDS solubility in the binary mixture compositions at various temperatures. The mean relative deviations (MRDs) were used as an accuracy criterion. The MRDs for fitting the solubility data of BDS in binary mixtures of ethanol + water are 6.6 % and 6.5 %, respectively. Some of apparent thermodynamic quantities such as, dissolution enthalpy, dissolution entropy, and Gibbs free energy change of dissolution process of BDS in all the mixed solvents were calculated according to van’t Hoff and Gibbs equations and correlated with the Jouyban- Acree model.

کلیدواژه ها:

Solubility ، Budesonide ، Binary solvent mixture ، Jouyban-Acree model