The effect of cyclic Carnosine peptide analogues on IsolatedMitochondria of A549 Cells

سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 480

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شناسه ملی سند علمی:

CBGCONF04_001

تاریخ نمایه سازی: 22 دی 1396

چکیده مقاله:

Our study showed that a various range of toxicity on A549 cells was resulted by the cyclic Carnosine analoguesusing MTT assay. Also, applying peptides on the mitochondria of A549 cells, a raise of mitochondrial reactive oxygenspecies (ROS) level, mitochondrial membrane potential (Δψm) collapse of the affected mitochondria were detected.Based on the overall results, cyclic Carnosine analogues, especially compounds 2c [Cyclo-(Pro-β-alanine-His-β-alanine-His)], 4c [Cyclo-(Pro-His-β-alanine-β-alanine-His)] and 6c [Cyclo-(Pro-β-alanine-His-His-β-alanine)], showedmore toxic activity than other Carnosine analogues, which would be encouraging to develop these peptide analogues asnew anticancer and complementary therapeutic agents for the treatment of lung cancer.

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نویسندگان

Abdolhamid Bamoniri

Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R. Iran.

Mohammadreza Gholibeikian

Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R. Iran.

MohammadHassan HoushdarTehrani

Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences,Tehran, I.R. Iran.

Bi Bi Fatemeh Mirjalili

Department of Chemistry, College of sciences, Yazd University, Yazd, I.R. Iran.