KF/HNTS CATALYZED ONE-POT THREE-COMPONENT BIGINELLI REACTIONS: AN EFFICIENT YNTHESIS OF 3,4- DIHYDROPYRIMIDIN-2-(1H)-ONE

Potassium fluoride/Holloysite nonotube (KF/HNTs) acts an active hetrogeneos base catalyst for Biginelli reaction. Here wehave describe An efficient one-pot synthesis of 3,4- dihydropyrimidine-2(1H)-one via a three-component reaction ofaldehyde, urea, and β-ketoester in the presence of a catalytic amount of (KF/HNTs). The experimental results showed thatthe KF/HNTs had high catalytic activity and it can be recycled without significant loss of activity. This protocols exhibitadvantages such as excellent yield, easy work-up and eco-friendly conditions.

کلیدواژه ها:

Biginelli reaction ، KF/HNTs ، 3 ، 4-dihydropyrimidin-2(1H)-ones ، multicomponent reaction ، solid base catalyst