THE RELEASE OF TETRACYCLINE HYDROCHLORIDE FROM THE POLYACRYLAMDE BASED NANOPOROUS HYDROGEL

In the present studies, the releases of tetracycline hydrochloride from the drug-loaded nanoporous hydrogels have been discussed, for the evaluation of the drug release mechanism and diffusion coefficients. It has been observed that diffusion exponent n has 0.68 value and gel characteristic constant k has 1.625x10 value, for the release of tetracycline hydrochloride in distilled water from the drug loaded hydrogels. Therefore, drug release from the drug loaded hydrogels through non-fickian or anomalous diffusion mechanism where the rate of drug diffusion and rate of polymer relaxation were comparable. The effect of pH on the release pattern of tetracycline has been studied by varying the pH of the release medium. However, in each release medium, the initial diffusion coefficient was observed to be more than the late time diffusion coefficient.

کلیدواژه ها:

Nanoporous hydrogel ، tetracycline hydrochloride ، polyacrylamide ، release