Ab initio Calculations on the H-Bond Interactions Between 1R-2R-pseudoephedrine and acrylamide

Recently, several experimental and computational researches have been conducted on molecularly imprinted polymers (MIPs) [1–2]. Moreover, various computational andexperimental studies have been performed to estimate the hydrogen bonding energies of several model systems [3–4].Hydrogen bonds play a vital role in biological systems [5] andthe biological properties are certainly affected by these linkages [6]. D-pseudoephedrine is used for the treatment ofnasal, sinus and Eustachian tube congestions. It is also indicated for vasomotor rhinitis and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis [7].