Electospinning of Cyclodextrin Functionalized Chitosan Nanofibers as Drug delivery System

Cyclodextrins(CDs) are a family of cyclic oligosaccharides, composed of D-glucose units[1].Grafting CD molecules onto chitosan(CS) reactive sites(CS-g-β-CD) may lead tomolecular carrier that increase the transport properties of CD and mucoadhesive properties of CS[2]. In this study wedescribe the preparation of a novel type of biodegradablenanofibers from a poly (vinyl alcohol)(PVA)/CS-g-β-CD blends via electrospinning.PVA was used as a non-ionogenicpolymer partner due to it being a non-toxic,watersoluble, biocompatible and biodegradable synthetic polymer[3,4,5].The effects of the spinning solutioncomposition on the average fiber diameters and morphology of the PVA/CS-g-β-CD electrospun fibres have been studied.