Supramolecular Copolymers and their Stimuli-responsive Micelles based on the Complementary Multiple Hydrogen Bonds of Nucleobases

Block copolymer micelles for drug delivery application are usually associated with several advantages. They improve the solubility and bioavailability of hydrophobic drugs in water.Furthermore, the nano size and narrow size distribution of micelles can effectively avoid renal clearance and nonspecificreticuloendothelial uptake. Therefore these micelles significantly protect the incorporated drugs from fast degradation and elimination in the body and prolong drug circulation time after intravenous administration