Synthesis and study of properties nanogel polymer based on cyclodextrin for drug delivery

Nanosized hydrogels (nanogels) have attracted enormous attention as multifunctional polymer-based drug delivery systems. Their efficiency is demonstrated both in drug encapsulation and drug release. In this work, we designed a novel nanogel polymer synthesized from chemically crosslinked alginate, using β-cyclodextrin (β -CD) that plays a dual role as a crosslinker and as a host molecule for enhanced binding of anticancer drug capecitabine (CAP), to achieve high drug loading level as well as controlled and sustained release of the anticancer drug. For this purpose, a series of novel β –CD crosslinked alginate were synthesized. The loading, complexation, and release of CAP in or from the nanogel were investigated.

کلیدواژه ها:

Nanogel polymer ، cyclodextrin ، alginate ، drug delivery