Synthesis and characterization of temperature-responsive PVCL-based hydrogel as a nancarrier for drug delivery

In this study, novel temperature responsive hydrogel based on Poly(vinylcaprolactam) (PVCL) were prepared system via reversible addition-fragmentation chain-transfer (RAFT) polymerization, where PEG- diacrylate served as cross-linker, and Lysine used as linking agent and applied for drug delivery. First, PVCL-PEG nano-hydrogel was prepared by RAFT polymerization in dioxane solvent, and then lysine added to PVCL-PEG. After that, doxorubicin as an anti-cancer drug, was conjugated to lysine moiety of as-prepared structure via Schiff-base reaction. Obtained nano-gels were characterized by FTIR, 1HNMR and their effective sizes were checked by dynamic light scattering analysis. LCST were determined and the drug release profile was tested in vitro.

کلیدواژه ها:

PVCL ، Hydrogel ، RAFT ، Doxorubicin