Effect of temperature on Tetracycline hydrochloride release behavior of PVA Hydrogel Nano-composite

Recently growing trends have been observed towards the PVA hydrogel composites based nanozeolite in drug delivery systems. This study considered to evaluate the release of Tetracycline hydrochloride via hydrogel Nano-composite and to assess the effect of temperature release behavior associated with Nano-composite.Reaction carried out by dissolving of sample components in 30 ml distilled water and placing into the water bath at 65℃ for gelation. The samples have been characterized by SEM, XRD and release behavior were studied by spectrometric methods at different temperatures (25, 30 and 35 °C).The constructed hydrogel Nano-composite showed 12% drug release for 6 hours at 30℃. Also it observed that drug release increased by an increase in temperature and decreased by temperature decrement. Moreover, XRD pattern and SEM images showed homogeneous morphology of Nano-composite.Taken together, results implicated that the constructed hydrogel Nano-composites can improve the antibiotic treatment

کلیدواژه ها:

Hydrogel Nano-composite ، nanozeolite ، drug release