TITLE: Graphene Oxide Fe3O4 magnetic nanoparticles Darshdh optimization factor for toxicity studies on lung cells

Graphene has attracted tremendous attention because of its unique electronic,1,2 thermal,3mechanical,4 optical properties5 and many potential applications in nanomaterials andnanotechnology . Its one-atom thickness and two-dimensional plane provide it with a largespecific surface area for the immobilization of a large number of substances including a widerange of metals, biomolecules, fluorescent molecules, drugs, etc. For biological applicationsof GO, Mohanty and Berry6 have reported the fabrication of a GO-based single-bacteriumbiodevice, label-free DNA sensor, bacterial DNA/protein and polyelectrolyte chemicaltransistor. Dai et al have found that the functionalized nanographene sheets are biocompatiblewithout obvious toxicity and have employed nanographene oxide for drug delivery. Otheradvantages of drug targeting are the potential to reduce the amount of drugs needed (having abiological and economic impact) and the opportunity to use drugs that would otherwise notbe able to be given to the patient. Graphene oxide with its two-dimensional nanostructuresand adjustable surface chemistry is an excellent candidate for targeted drug delivery.