Study of Adsorption and Kinetic Release of Azithromycin onto MCM-41 Mesoporous

In the last decade Study on mesoporous silica nanoparticles in order to drug deliveryapplications has Significant grown. Mesoporous silica materials because of high surfaceareas, high pore volumes and well organized porosity, developed their applications in thefields of adsorption, catalysis, separation and drug delivery systems [1]. Azithromycin ishighly lipophilic with poor water solubility antibiotic and relatively low oral bioavailabilityof 37% after ingestion [2]. Acid degradation of the drug before absorption and possibly,incomplete absorption accounts for low bioavailability [3]. In this research was used theMCM-41 mesoporous as carrier in order to increasing bioavailability of pH sensitiveazithromycin and improving antibiotic shelf-life. In addition, in this study was obtainedoptimum conditions to increase drug loading on the mesoporous , determined the adsorptionthermodynamic parameters and investigated drug release from mesoporous loaded byazithromycin.