Kinetic Study of Adsorption of Methotrexate on Mesoporous Silica nanoparticles as a Drug Delivery Carrier System

Mesoporous silica nanoparticles (MSNs) have recently brought new potential innanomedicine due to their large surface area and pore volume, tunable mesopore size andbiocompatibility [1–3]. Although several studies have been reported on the effects of in vivoor in vitro antitumor activity and tumor targeting of drug–MSN complex based on theadsorption, but very little is known about the adsorption behavior and thermodynamic ofanticancer drug on MSNs. In this research we studied thermodynamic and kinetic study ofMethotrexate on MCM-41.