Docking studies on the binding properties of Methotrexat to Human serum albumin

Plasma proteins play an important role in the transportation and deposition of substances suchas fatty acids, hormones and medicinal drugs in the circulatory system. The interaction ofhuman serum albumin with a wide range of chemically synthesized drugs used in medicinemay influence their bioavailability and effectiveness. As a result, several studies haverecently focused on revealing the molecular details of these interactions [1,2].Methotrexat(MTX) is an inhibitor of tetrahydrofolate dehydrogenase and prevents theformation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential componentof DNA(figure1). Disposition and transportation of anticancer drugs by human serumalbumin (HSA) affect their bioavailability, distribution and elimination. In this study, theinteraction of MTX with HSA was investigated by molecular docking simulations.