Electrochemical oxidation of acetaminophen in the presence of diclofenac

Electrochemical oxidation of acetaminophen has been studied in the presence of diclofenac in aqueous solutions, using cyclic voltammetry and controlled-potential coulometry [1]. Obtained results indicate that the N-acetyl-p-benzoquinone-imine (NAPQI) derived from acetaminophen participate in Michael addition reactions with diclofenac and via EC reaction mechanism convert to the corresponding product (scheme 1). In this work, we derive product with good yields basedon electrochemical oxidation under controlled potential conditions in aqueous solutions, without toxic reagents and solvents at a carbon electrode in an undivided cell, using an environmentally friendly method [2,3]. Furthermore, based on an EC mechanism, the homogeneous rate constant of the chemicalreaction interposed between electron transfer were estimated by comparing the experimental cyclic voltammetric responses with the digital simulated results

کلیدواژه ها:

Acetaminophen ، Diclofenac ، Cyclic voltammetry ، Digital simulation ، EC mechanism