Electrochemical oxidation investigation of acetaminophen drug in the presence of diethylamine by electrochemical methods

The investigation of electro-oxidation of acetaminophen shows that the formed quinonimine is quite reactive and can be attached as a Michael acceptor by nucleophile , producing variouscompounds through the 1,4 - Michael addition reaction . On this direction , the electro-oxidation of acetaminophen has been studied in absence and presence of Diethylamine as a nucleophile by using cyclic voltammetry and controlled-potential coulometry in phosphate buffer (pH=8) as asupporting electrolyte . The results indicate that the quinonimine formed from the oxidation of acetaminophen with arriving in a 1,4 - Michael addition with Diethylamine convert to a new derivative . According to obtained results the reaction mechanism of electrooxidation ofacetaminophen in the presence of Diethylamine is a successive ECE mechanism. The homogeneous rate constant were estimated by comparing the experimental cyclic voltammetric responses with the digital simulated results.

کلیدواژه ها:

Acetaminophen ، Diethylamine ، ECE mechanism ، Cyclic voltammatry