Investigation of potentiometric Behavior of Amoxicillin by Ion-Selective Electrode with Nano Clinoptilolite Doped with Cu2+Ion

The objective of this work is study the potentiometric behavior of amoxicillin (AMX) at nano zeolite-modified ion selective electrode dopped with copper(II) ions (Cu2+ ) . Zeolite that used isclinoptilolite that made it into nano particales with ball-mill method. One of the properties of zeolites is ability to ion exchange and applied here for making modifier [1]. Cu2+ work as catalyst to oxidize AMX with nano clinoptilolite this aim increase because nano particles havebetter ratio surface to volume. Modifier that applied in electrode identify by XRD method and SEM.In this work for preparation ion selective electrode and mixed dioctyl phthalate and Cu(II)-NC and poly vinyl chloride and tetrahydrofuran. Then glassy pipes with a diameter of 2 mm inserted in mixture and drying in room temperature reviewed the electrodes response in absent and present of AMX by potentiometric method. By using this electrodes experimental parametersaffecting on the efficiency including solution pH, temperature and modifier percent wereexamined and optimized. β-lactamic antibiotics (including here AMX) are the oldest and important antimicrobial agent that are still widely used to treat human and animal diseases.Various analytical methods have been reported for the separation and determination of MX based on spectrophotometric [2], [3] and [4], fluorimetric [5] capillary electrophoresis [6] and [7], high-performance liquid chromatography [8] and [9] and electrochemical methods [10-12].

کلیدواژه ها:

potentiometry ، zeolite modified electrode ، amoxicillin