Voltammetric Citalopram Nanosensor

In this work, electrochemical behavior of Citalopram (CTP) was studied. Because of simplicity, rapidity, high sensitivity and selectivity, vaoltammetric nanosensors are very important in thedrug determination. CTP is an antidepressant drug of the selective serotonin reuptake inhibitor class that is used for the treatment of severe depressive disorders [1-3]. Silver nanoparticles and 1, 4-Dihydropyridines were used to fabricate a modified carbon paste electrode as anelectrocatalyst and organic selective agent, respectively. 1, 4-Dihydropyridines represents an important class of compounds that arises in many biological products such as vasodilators, antitumor and anti-diabetic agents. Silver nanoparticles with the general characteristics ofnanoparticles such as catalytic properties, conductivity, high surface area, strengthening and so arises as a good option to modify carbon paste electrodes. The effects of various experimentalfactors such as pH, supporting electrolyte and potential scan rate have been investigated. The limit of detection and the linear range were found to be 1.50 × 10-5 and 1.0 × 10-2 to 1.0 × 10-4 M of CTP, respectively. Finally, the proposed nanosensor was applied for determination of CTP in biological specimen and pharmaceutical products, successfully.

کلیدواژه ها:

Citalopram ، Silver nanoparticles ، 1 ، 4-Dihydropyridines ، cyclic voltammetry