Antinociceptive and anti-inflammatory activity of Pycnocycla bashagardiana mozaff essential oil in rats

Introduction: Pycnocycla bashagardiana mozaff is an endemic species found only in Iran. It is commonly distributed in Jask County, Hormozgan Province. Due to the presence of myristicin as the major component, antinociceptive and anti-inflammatory properties of P. bashagardiana essential oil are proposed. Materials and methods: The carageenan-induced Paw Edema and Hot-plate methods were used for inflammation and pain evaluation in rat and mice respectively. Pycnocycla bashagardiana mozaff essential oil (PBMEO50, 100, 200 and 400 mg/kg BW, IP), saline and morphine (5 mg/kg, IP) were administered and then Hot plate test was performed on all animals individually in 15th, 30th, 45th and 60th min after treatment. The anti-inflammatory property of PBMEO (200 and 400 mg/kg, IP) assessed by carageenan-induced paw edema method in 30min, 1, 2, 3, 4 hours after carageenan injection in rats. Comparisons between the groups were carried out using the analysis of variance (ANOVA), and post hoc Tukey's test. Results: In Hot-plate test, the studied dose of PBMEO was not effective. However, in carageenan test, all doses of PBMEO significantly reduced the paw edema in compared to control animals (p<0.05). Anti-inflammatory activity of PBMEO (200 and 400mg/kg, P<0.05) was found to be more than Mefenamic Acid (30mg/kg). The major components of the oil were characterized as myristicin, which might be responsible for anti-inflammatory activity. Conclusion: The results suggest that PBMEO possesses biologically active constituents that have significant peripheral anti-inflammatory effects

کلیدواژه ها:

Pycnocycla bashagardiana mozaff essential oil ، Antinociceptive ، Anti-inflammatory ، Carageenan test ، Rat ، Mice