Antidiabetic effect of Ziziphus Jujuba fruit in Alloxan induced diabetic male rats

سال انتشار: 1395
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 646

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شناسه ملی سند علمی:

MPHBS01_108

تاریخ نمایه سازی: 22 آبان 1395

چکیده مقاله:

Introduction: Tradit traditional plant medicines are used throughout the world for a range of diabetic complication. Recently, Ziziphus Jujuba fruit has been taken into consideration in the treatment of diseases, due to not having any side-effects. In the present study, the antidiabetic effect of Ziziphus Jujuba fruit was investigated in Alloxan-induced diabetic rats. Materials and methods: In this experimental study, animals were divided into 6 groups (8 rats/group): healthy group, diabetic group, in which diabetes was induced by intraperitoneal (i.p.) injection of Alloxan (at dose of 120 mg/kg) and experimental groups, which were treated with i.p. administration of hydroethanolic extract (at doses of 50, 100, 200, and 300 mg/kg) for 14 days. The diabetic control group was treated daily with saline. After 14 days, the animals were anesthetized with ether and sampling of blood and liver was done. Liver sections were stained with haematoxylin-eosin. Serum levels of glucose, total cholesterol, triglyceride, LDL-c, HDL-c, urea, uric acid, enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (AP), were measured using kit and liver histopathological damages. Results: The treatment of Alloxan significantly increased serum levels of glucose, urea, ALT, AST, AP and liver histopathological damages in diabetic control animals compared to the healthy group. Treatment with hydroethanolic extract of Ziziphus Jujuba fruit for 14 days (at doses of 50, 100, 200, and 300 mg/kg), significantly decreased serum levels of glucose, urea, ALT, AST, AP and histopathological damages, while increased serum HDL level compared to the diabetic control group. Conclusion: Hydroethanolic extract of Ziziphus Jujuba fruit has antidiabetic effect on diabetic animals. Therefore, this plant is a good candidate for the treatment of diabetes mellitus

نویسندگان

Hossein Ahmadian

Department of Biology, College of Biological Sciences, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran

Maryam Eidi

Department of Biology, College of Biological Sciences, Varamin-Pishva Branch, Islamic Azad University, Varamin, Iran.

Mostafa Hamidi Nomani

Department of Biology, College of Biological Sciences, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.

Roya Abbasi

Department of Biology, College of Biological Sciences, Varamin-Pishva Branch, Islamic Azad University, Varamin, Iran.