The prevalence of giardiasis in duodenal biopsies of celiac and non-celiac cases in Ali ibn Abi Talib hospital's referred patients in Zahedan in 2015-2016

Introduction: Giardiasis is a diarrheal disease caused by Giardia lambelia. Celiac disease, gluten sensitivity enteropathy, is an autoimmune disease that associated with malabsorption. The purpose of the current study was to determine the prevalence of giardiasis in duodenal biopsies of celiac and non-celiac patients with dyspepsia. Materials and methods: It is a descriptive-analytic study on 500 duodenal biopsies have been taken from patients with dyspepsia who was referred to Ali ibn Abi Talib hospital of Zahedan in 2015-2016. Celiac and non-celiac patients biopsies according to previous pathological diagnosis had been classified. Presence or absence of giardiasis in biopsies was studied. Statistical analysis of the data was done by SPSS software. The data statistically analyzed using Chi-square test, 95% confidence interval, percentage, mean and standard deviation. (P-value < 0.05). Results: In 500 duodenal biopsies, 8 cases had giardiasis (6/1%), 35 cases had celiac disease (7%), 465 cases didn't have celiac disease (93%). In celiac cases there was no giardiasis, 8 giardiasis (7/1%) was observed in non-celiac cases. 274 cases were male (54.8%) and 226 cases (45.2%) were female. 19 cases (54.3%) of male cases and 16 cases (45.7%) of female cases diagnosed to have celiac disease. In non-celiac cases, 3 males (1.2%) and 5 females (2.4%) was diagnosed giardiasis. Conclusion: The results indicated that giardiasis didn't have a significant role in dyspepsia and celiac disease, however giardiasis had a more significant role in dyspepsia. It is better that duodenal biopsy take while endoscopy performs to prevent the duodenal abnormality such as celiac disease and giardiasis because observational findings of endoscopy have inadequate sensivity, also celiac disease have a high incidence of non-specific signs.

کلیدواژه ها:

Giardiasis ، Duodenal biopsy ، Celiac disease