مطالعه اثر کلراید سدیم بر توانایی جهش زایی نیتریت سدیم

The cocarcinogenicity of sodium chloride was assayed by in vivo experiments. The investigation was carried out in 18 male rats. The rats were 8 weeks old and weighted 90 grame and they were exposed to the same environmental conditions. Rats were divided into 3 groups: 1- Control group, 2- Rate treated twice, with an interval of 24 hours, with sodium nitrite in does 5.18 mg/ kg body weight, 3- Rats given nitrite the same as second group, 24 hours after a single application of 1 ml of saturated sodium chloride solution (29 percent) to investigate the effect of sodium chloride as a cocarcinogenesis. Bone marrow biopsy samples were obtained for all three groups. Micronuclei index was evaluated an all groups. Sodium chloride and nitrite induced signicant increase in micronuclei count in the third group (P<0.001). But nitrite without sodium chloride did not induce any significant increase of the number of micronuclei. This data suggest a possible role of cocarcinogenicity for sodium chloride when used prior to sodium nitrite in rats.