Rapid/Simple Synthesis of Diopside/Magnetite as a Novel Magnetic-Bioactive Nano Composites Usi ng Bone Cancer Therapy Hyperthermia Treatments

Hyperthermia treatment consists of heating target tissues to temperatures between 41° to 46°C. At these temperatures, malignant cells are destroyed whereas healthy cells do not undergo important or nonreversible damage. This paper presents a simple method for the rapid synthesis of diopside/magnetite composite particles. In this method, super paramagnetic magnetite nanoparticles are first synthesized by co-precipitation using ferrous chloride and ferric chloride. Immediately following the synthesis, diopside, CaMgSi2O6, particles were Sol-Gel method. Then, diopside/magnetite composites synthesized by wet milling diopside synthesized in a dispersed suspension of magnetite nanoparticles, 30-65 nm, during which the magnetite nanoparticles are incorporated into the bioactive diopside matrix. We observed that the resultant magnetite/diopside nanocomposites possessed a homogeneous dispersion of magnetite nanoparticles, characterized by an absence of large aggregates. When this material was subjected to an alternating magnetic field, the heat generated increased with increasing magnetite concentration. For a magnetite concentration of 20 wt. %, a temperature increase about 10 ºC was achieved in less than 1 min. These results suggest that our composites exhibit good hyperthermia properties and are promising candidates for using bone cancer therapy hyperthermia treatments.

کلیدواژه ها:

Magnetite-Bioactive ، Diopside ، Hyperthermia ، Nano composite