In Silico Analysis of rs2278414 and Its Related MicroRNAs in Breast Cancer

Breast cancer is the most common cause of cancer death among women worldwide.Aberration in signal transduction pathway of Znf350family in human tumors is a commonphenomenon. Znf350as an oncogene and also tumor suppressor is one of the members ofZnf family. Znf350 overexpression has been observed in approximately 50% of breast cancercases. miRNAs are the large subgroup of noncoding RNAs with 18-25 nucleotides inhibitingthe expression of target genes by means of binding to their 3’UTR. They also can playrole as an oncogene and/or tumor suppressor. In recent years, the association of some SNPslocated in either miRNA seeds or 3’UTR of their target genes with the risk of breastcancer have been proved in some populations.

کلیدواژه ها:

Breast Cancer ، Znf350 ، MicroRNA ، Prognosis ، rs2278414 ، SNP