Fabrication and optimization of PLGA nanofibrous by electrospinning method as tissue e ngineering scaffold

In this study, nanofibers of poly (lactide-co-glycolide) (PLGA) were electrospun through a single nozzleby electrospinning method. This method successfully produced both randomly-oriented and alignedPLGA nanofibrous scaffolds. However, the average fiber diameter of PLGA nanofibrs was evaluated byanalyzing the SEM images used Image J software. Optimization of fiber diameters was carried out invarious conditions. The optimum conditions were obtained with a polymer solution concentration of %42(w/v) at a feeding rate of 52%0 ml/h and a high voltage of 1.20 kV. The distance of collector from theneedle tip was 15 cm. Randomly oriented and aligned PLGA nanofibrous matrices were successfullyprepared.