Effect of vaginal misoprostol on pregnancy rate after intrauterine insemination: a randomized controlled trial
سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 422
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شناسه ملی سند علمی:
JR_IJRM-13-1_002
تاریخ نمایه سازی: 16 شهریور 1395
چکیده مقاله:
Background: Intrauterine insemination (IUI) is one of the most appropriate and cost-effective methods in infertility treatment. Objective: We aimed to investigate effect of vaginal misoprostol on pregnancy rateafter IUI. Materials and Methods: Two hundred and ten infertile women who were referredto Infertility Clinic of Alzahra Hospital by an indication of IUI during 2012-2013 were randomly assigned to receive 200 μg vaginal misoprostol (n=105) or vaginalplacebo (n=105) after IUI. For detecting pregnancy, past 2 weeks, beta human chorionic gonadotropin evaluation was made and if positive, transvaginalsonography was done for evaluation of pregnancy 2-3 weeks later and clinical pregnancy was recorded.Results: Pregnancy had been noted in 24 patients in misoprotol (22.9%) and 27patients in placebo (25.7%) groups that this difference was not significant (p=0.748).In misoprostol group, 3 case of nausea and vomiting (2.9%) had been observed. Conclusion: According to the results, administering 200 μg vaginal misoprostol after IUI doesn’t have significant effect on the success rate of IUI.
کلیدواژه ها:
نویسندگان
Ziba Zahiri sorouri
Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Rasht, Iran.
Maryan Asgharnia
Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Rasht, Iran.
Ameneh Gholampoor
Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Rasht, Iran.