Green synthesis without protecting of N-alkyl indols and indole N-acetamide and Isoindole-1,3-dione by the catalyst system MNCF@ ionic liquid of drivetives imidazolium[imidazolium carbonat([BMIM]CO3 )] via N–H bond activation of indole and Isoindole-1,3-dione

N-alkyl indols is an aromatic organic compound and an odor similar to oxindol. It occurs naturally as a constituent of petroleum-related deposits such as lignite tar. N-alkyl indols has no household use. It is used primarily in industry and research. Being a heterocyclic compound, N-alkyl indols finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs. It is also used in the manufacturing of dyes. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization[1]. N-alkyl indols derivatives possessing an alkyl group as one of the substituents on the five-membered ring are of immense medicinal value because of their promising pharmacological properties. also Indole compounds have many medicinal properties and can be seen in most of the enzymes and drugs. Limited methods for the synthesis of these compounds has been reported so far. Unfortunately, high energy costs and high time. In this study, we've tried to include as-alkyl indole using a green catalyst the minimum cost and time and energy we produce . Our production strategy goals of green chemistry, green imidazole carbonat catalyst was first and then using the catalyst synthesis of derivatives Nalkyl indols have the N- alkyl indole in the form of a sample of liver drug in the structure shown( fig.1).

کلیدواژه ها:

N–H activation ، N-alkyl indols ، green chemistry