Optimization of sustained release delivery Olanzapine system

The objective of this study is to develop controlled release formulation of water insoluble Olanzapine (OZ), using Glycerol monooleate (GMO) and Polyethylene glycol (PEG 300). A Box-Benkhen response surface methodology was applied to design gel system with 3 factors with an initial drug containing within the range of 2-4%, weight ratio of GMO/water (w/w) in the range of 2-4% and weight ratio of PEG 300/GMO (w/w) in the range of 2-6%. Dependent variables include entrapment efficacy (EE %), percentage of release at 12th and 168th hr and viscosity. A quadratic model as an appropriate equation has been selected to fit the entrapment efficacy (EE %). Percentage of release at 12th and 168th hr and for viscosity a cubic model is selected. Optimization of liquid crystalline phase was carried out based on statistical concept of experimental design. Validation test was carried out under optimum conditions of the parameters predicted by the polynomial model.Determination of liquid crystalline phases has been displayed by polarized light microscopy. In addition, entrapment efficacy was measured spectrophotometerically at 265 nm. In vitro release studies of OZ from prepared samples were conducted in PBS (pH 6.8) and drug was analyzed by spectrophotometer at 265 nm

کلیدواژه ها:

Cubic phase ، Liquid crystalline phase ، Box-Benkhen response surface experimental design methodology