Synthesis and antibacterial activities of some sulfonamide derivatives

Sulfonamides were intensively investigated as the first effective antibacterial agents.Some sulfonamides were the firstdrugs with antituberculous effects, but now they are generally considered to have no clinical usage on Mycobacteriumtuberculosis. In this project firstly Aniline was acylated with acetic anhydride. Then N-phenylacetamide was reactedwith HSO3Cl to produce the corresponding sulfonyl chloride. After that different amines were added 4-acetamidobenzene-1-sulfonyl chloride and the obtaine product was reacted with H2O and HCl to produced sulfonamide.The advantages of this procedure are operational simplicity, excellent yields, easy work up and green environmentalimpact. The antibacterial activity of the synthesized compound is under evaluation.

کلیدواژه ها:

Aniline ، sulphonamide ، Antibacterial