Synthesis of new hybrids compounds of quinoline with 5- nitroheteroaryl-1,3,4-thiadiazolidine

Quinoline derivatives are prevalent in a variety of pharmacologically activesynthetic and natural compounds, especially with anti-malarial and antimicrobialactivities. Also, anti-cancer, anti-inflammatory, anti-neoplastic, antifungal,anti-viral and anti-protozoal activity have been reported with quinolinederivatives. On the other hand, the anti-parasitic property of nitroheteroaryl-1,3,4-thiadiazole derivatives was well established and their linkage with otherheterocycles often modulates their biological activities. Considering theimportance of these heterocyclic rings, were synthesized novel quinoline and 5-nitroheteroaryl-1,3,4-thiadiazole hybrids with different linkers between them.