Prepration of synthetic rotein nanoparticles as drug delivery vehicles

سال انتشار: 1383
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 1,478

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شناسه ملی سند علمی:

NICEC09_090

تاریخ نمایه سازی: 14 فروردین 1386

چکیده مقاله:

Pharmaceuical industry can widly use protein nanostructure because they mimic the drug delivery vehicles such as viruses,at the same time they are non-antigenic and biodegradable. This study objects to manufacture bovine serum albumin (BSA) nanoparticle by coacervation method following by crosslinking with glutaraldehyde. It is shown that the shape of nanoparticles is semispherical and the size distribution of them is 80- 280 nm. The mean size is 150 nm.The particl size is critical parameter in particular for invivo behaviour of nanoparticles after injection.

نویسندگان

Aghajani

Biotechnology group, Dept.of Chemiacl Engineering, School of engineering, Tarbiat Modarres University

Jahashahi

Nanoparticleslab, Dept.of Chemical Engineering, Faculty of engineering, University of Mazandaran (UMZ)

S.A. Shojaosadati

Biotechnology group, Dept.of Chemiacl Engineering, School of engineering, Tarbiat Modarres University