Corticosteroids-Loaded Nanocapsules: Preparation and Characterization

Now adays to treat the disease usually a high dose drug are used that has a wide side effects in tissues and cells. One of the most common solution for this problem is drug delivery system. In this study, corticosteroids-loaded nanocapsules were prepared by interfacial deposition of poly (ε -caprolactone) PCL. Major activity in this area has entered on aliphatic polyesters, principally due to the favorable toxicology of their degradation product. Polymeric nanoparticles have been extensively studied as drug carriers because they have the ability to control the release of a variety of drugs, to increase the drug stability and to reduce their toxicity .In the last years, several researchers have shown the potential of the poly(ε-caprolactone) PCL nanocapsules as drug delivery systems . An original method called interfacial deposition technique have developed to obtain nanocapsules which are made of an oily core containing the drug surrounded by a thin polymeric wall. In this investigationthe nanoparticle size distribution were measured by photon correlation spectroscopy then, we can saw nanotechnological properties such as nanometric mean size (194.3 nm) and negative zeta potential(-30.3 mv). The structure and morphology of nanocapsules were studied by UV, FT-IR and SEM techniques and cortisone was assayed by high-performance liquid chromatography (HPLC).

کلیدواژه ها:

nanoencapsulation ، drug delivery ، polymeric nanoparticles