Functionalized DOX nanocapsules by Iron oxide nanoparticles for targeted drug delivery

The drug capsulation was used to release and to targeted delivery in determined time, placeand temperature or pH .The DOXnanocapsules were to reduce and to minimize theunwanted side effects of drug. In this paper, the encapsulation methods of doxorubicin (DOX)and the labeled it by the magnetic core of iron (Fe3O4) has been studied .The Fe3O4 wasconjugated with DOX via hydrazine bond . The solution were capsuled by the sensitivepolymer of heat or pH such as chitosan-g-poly (N-isopropylacrylamide-co- N,Ndimethylacrylamide),dextran-g-poly(N-isopropylacrylamide-co-N , N - dimethylacrylamide)and mPEG-G2.5 PAMAM by hydrazine bond. The drug release was very slow at temperaturelower than 380C.There was a rapid and controlled drug release at temperature higher than380C. According to experiments,the use mPEG-G2.5PAMAM is the best method of DOXnanocapsules synthesis. Because in this method, the drug delivery time to certain place islower than others methods and the percent of release drug is more.The synthesized magneticcarrier system has potential applications in magnetic drug-targeting delivery and magneticresonance imaging.

کلیدواژه ها:

Drug carrier ، Drug release ، Doxorubicin ، Iron oxide NPs