Comparative effects of sodium fluoride varnish with and without CPP-ACP addition on Streptococcus mutans counts and salivary calcium and phosphate levels in preschool children

Objective: This study compared the effects of ۵% sodium fluoride varnish (NaF) with those of ۵% NaF varnish containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on Streptococcus mutans (S. mutans) counts in dental plaque and salivary calcium and phosphate levels in preschool children.Methods: This randomized single-blind clinical trial included ۳۳ caries-free children aged ۳–۶ years who were classified as having a moderate-to-high risk of future caries development according to the American Academy of Pediatric Dentistry (AAPD) caries risk assessment guidelines. The participants were randomly allocated (۱:۱) to receive either sodium fluoride (NaF) varnish alone (n = ۱۶) or NaF varnish containing CPP-ACP (n = ۱۷). S. mutans counts in dental plaque and salivary calcium and phosphate concentrations were assessed at baseline and follow-up intervals. Data were analysed using repeated-measures ANOVA at the significance level of P < ۰.۰۵.Results: Plaque S. mutans counts changed significantly over time (P < ۰.۰۰۱), but did not differ significantly between the two groups (P > ۰.۰۵). Salivary calcium and phosphate concentrations showed no significant changes over time or differences between groups (P > ۰.۰۵).Conclusions: The addition of CPP-ACP to NaF varnish did not provide a statistically significant additional benefit in reducing plaque S. mutans counts or changing salivary calcium and phosphate levels compared with NaF varnish alone.

کلیدواژه ها:

Calcium Phosphates ، Dental Caries ، Dental plaque ، fluorides ، Saliva ، Streptococcus mutans