The effectiveness of omega-۳ fatty acids supplementation on health outcomes in women with breast cancer: A systematic review

This study aimed to evaluate systematically the impact of omega-۳ fatty acids supplementation on the health outcomes of women with breast cancer in the electronic databases (PubMed, Scopus, ProQuest, Web of Science, and Cochrane Library) for interventional studies. The risk of bias and the quality of the included articles were assessed through the guidance of the Cochrane Collaboration Handbook. Out of ۳۶۷۶ identified articles, ۱۱ articles were included in this study. Median time to progression and overall survival significantly improved. Surgical site healing complications and infection rates indicated a significant reduction. There was a significant decrease in perceived stress, sleep disturbance, depression, pain, joint stiffness, and fatigue over the course of the intervention. Omega-۳ fatty acids significantly increased the total serum n-۳, EPA, and DHA versus it decreased n-۶:n-۳ ratio, total leukocytes, lymphocytes, and leptin. Omega-۳ fatty acids may cause an improvement in physical, mental, and some metabolic indices.

کلیدواژه ها:

Breast cancer ، Omega-۳ fatty acids ، Adjuvant therapy ، Health ، Systematic review