۶-Amino-۴H-pyran derivatives as potential anti-microbial and amyloid aggregation inhibitory agents

Pyran and its derivatives are an important group of heterocyclic compounds. These compounds are used in chemistry and pharmacy. This study investigates the anti-microbial and anti-Alzheimer's effects of ۶-amino-۴H-pyran derivatives. ۶-amino-۴H-pyran derivatives were produced from ethyl acetoacetate, with benzaldehydes and malononitrile in the presence of nano–MgO in water at ۸۰ ºC by remarkable efficiency. MIC, MBC, and disc diffusion methods were performed to evaluate the antibacterial effects of five ۶-amino-۴H-pyran derivatives. The Congo red uptake method was used to determine the degree of inhibition of amyloid fibril production from Bovine serum albumin. For all five ۶-amino-۴H-pyran derivatives, the minimum inhibitory concentration for both Escherichia coli (PTCC ۱۳۳۰۱) and Staphylococcus aureus (PTCC ۱۱۱۲) was observed in a ۱:۸ (v/v) dilution rate (۱۲۵ μg/ml), and the minimum bactericidal concentration in gram-negative and gram-positive bacteria was in a ۱:۴ (v/v) dilution rate (۲۵۰ μg/ml). Also, the best inhibitory properties for amyloid fibrils were seen at ۱۲%, ۴%, ۸%, ۱۶%, and ۱۲% (w/v) solutions for ۴a–۴e compounds, respectively. The most significant reduction in the production of amyloid fibrils was observed for benzyl ۶-amino-۴-(۳-chlorophenyl)-۵-cyano-۲-methyl-۴H-pyran- ۳-carboxylate (۴d). The identified antimicrobial activity and inhibition of amyloid fibril production by ۶-amino-۴H-pyran derivatives indicate a potential area for future therapeutic development. However, comprehensive studies are needed to establish their efficacy in addressing complications of infectious diseases and Alzheimer’s.

کلیدواژه ها:

Alzheimer ، ۶-amino-۴H-pyran derivatives ، Nano MgO ، Amyloid ، Anti&ndash ، microbial