Effects of Eight Weeks of Swimming Training on Fetuin-A, FGF۲۱ Levels, and Oxidative Stress in Liver Tissue of Mice with Type ۲ Diabetes

Objective: The aim of the present study was to investigate the effect of eight weeks of swimming training on Fetuin-A, FGF۲۱, and oxidative stress levels in the liver tissue of type ۲ diabetic mice. Materials and Methods: A total of ۳۲ male BALB/c mice were randomly assigned to four groups: healthy control (HC), healthy training (HT), diabetic control (DC) and diabetic training (DT). Type ۲ diabetes was induced using a high fat diet combined with streptozotocin. Swimming sessions were conducted five days/week over eight weeks with progressive intensity. Liver samples were harvested ۴۸ hours after the final session. Fetuin-A and FGF۲۱ gene expression were measured via real-time PCR, and ROS levels were quantified using a fluorescence assay. One-way ANOVA with Tukey's post hoc test was used for comparisons (P≤ ۰.۰۵). Results: Diabetes induction significantly increased Fetuin-A, FGF۲۱, and ROS levels in the DC group compared to the HC group (P< ۰.۰۰۱). The adaptation resulting from eight weeks of swimming training in the diabetic exercise group probably decreased Fetuin-A and ROS and increased FGF۲۱ (P< ۰.۰۰۱). In the HT group, decreased Fetuin-A and increased FGF۲۱ were also observed compared to the HC group (P< ۰.۰۰۱). Conclusion: Swimming training modulates key hepatokines(decreasing Fetuin-A and increasing FGF۲۱) and reduces oxidative stress, thereby creating a more favorable metabolic environment in the liver of diabetic mice. These findings in the studied group suggest that swimming training could probably be considered as a non-pharmacological strategy.

کلیدواژه ها:

Type ۲ diabetes ، Swimming training ، Fetuin-A ، FGF۲۱ ، Oxidative stress ، Liver