Determination of cefaclor in aqueous solution using multiwalled carbon nanotubes solid-phase extraction cartridge

Cefaclor is a well-absorbed orally active cephalosporin antibiotic. Cefaclor can specifically bind to specific for penicillin-binding protein ۳ (PBP۳). Cefaclor can be used for the research of depression and kinds of infections caused by bacteria, such as respiratory tract infections, bacterial bronchitis, pharyngitis and skin infections. One of the most important chemical properties of carbon nanotubes is having a hydrophobic surface, and because of that many compounds and materials can be retained on the surface of these nano structures. In this study, by using this feature of carbon nanotubes, their ability in adsorption of cefaclor at trace amount from aqueous solution has been tested. Samples were strongly adsorbed by carbon nanotubes and acceptable recoveries were obtained. Analyses of samples were done by high performance liquid chromatography and UV. Limit of detection of cefaclor under optinuum conditions is ranged between ۰.۱۵-۰.۲ /ml. recoveries of spiked sample analysis ranged from ۸۶.۸% to ۸۸.۴%

کلیدواژه ها:

carbon nanotubes ، solid-phase extraction ، high performance liquid chromatography ، Cefaclor