Effect of Resistance and Interval Training on Serum Melatonin and Expression of Its Receptors (MTNR۱A and MTNR۱B) in the Pancreas Tissue of Diabetic Rats

Objective: In addition to controlling seasonal and circadian rhythms, melatonin has been recognized as a potential gene associated with type ۲ diabetes (T۲D). This study aimed to investigate the impact of resistance and interval training on serum melatonin and its receptors expression (MTNR۱A, MTNR۱B) in pancreatic tissue of type ۲ diabetic rats. Materials and Methods: To achieve this, T۲D was established in ۲۱ male Wistar rats through an ۸-week high-fat diet followed by an intraperitoneal injection of STZ (۲۵ ml/kg), then were divided to control (no exercise), resistance (resistance training), and interval (interval training) groups. Exercise interventions lasted ۸ weeks (۵ time/weekly). Fasting glucose, serum insulin and melatonin, beta cell function, MTNR۱A and MTNR۱B expression in pancreatic tissue were assessed ۴۸ hours following lasting exercise and analyzed among groups using a one-way ANOVA test. Results: Both resistance and interval training led to significant increase in insulin and beta cell function and significant decrease in glucose, serum melatonin, MTNR۱A and MTNR۱B expression in pancreatic tissue compared with control group (P< ۰.۰۵). Significant difference were not observed in all variables between interval and resistance groups (P> ۰.۰۵). Conclusion: Resistance and interval training are associated with increased insulin in T۲D rats, and this improvement may be attributed to decreased melatonin and its receptor expression in pancreatic beta cells. Additional research is required to elucidate alternative mechanisms that contribute to elevated insulin levels.

کلیدواژه ها:

Type ۲ diabetes ، Melatonin receptors expression ، Insulin synthesis ، Exercise training ، Beta cell function