Pulmonary sclerosing pneumocytoma: Novel [۱۸F]FDG uptake pattern observed in follow-up PET/CT imaging

A ۳۶-year-old man with an incidentally detected right upper lobe pulmonary nodule underwent serial [۱۸F]F-Fluorodeoxyglucose ([۱۸F]FDG) positron emission tomography (PET)/computed tomography (CT) examinations over a ۱۶-month period to assess metabolic activity and guide clinical management. Initial imaging demonstrated no increased metabolic activity in the pulmonary nodule, supporting a conservative follow-up strategy. However, subsequent [۱۸F]FDG PET/CT examinations demonstrated a gradual increase in metabolic activity, initially raising concern for malignant transformation and prompting biopsy, which ultimately confirmed pulmonary sclerosing pneumocytoma (PSP). Retrospective analysis revealed that the increased [۱۸F]FDG uptake was not localized to the pulmonary nodule itself but rather to adjacent distal vascular structures. This case highlights a pattern of [۱۸F]FDG uptake associated with vascular endothelial proliferation in PSP, emphasizing the importance of careful PET/CT interpretation and the potential to non-invasively characterize the lesion based on this uptake pattern.

کلیدواژه ها:

False-positive ، Pitfall ، Pulmonary sclerosing hemangioma ، Solitary pulmonary nodule ، Radiopharmaceuticals