Prevalence of Primary Ovarian Insufficiency, Early Menopause and their Associated Factors among Menopausal Women: Results from the AZAR Cohort study in Iran

Background & aim: Primary ovarian insufficiency (POI) and early menopause are among the primary causes of female infertility. Thus, the present study evaluated the prevalence of POI and early menopause and identifies the associated factors in postmenopausal women in Shabestar, Iran.Methods: This cross-sectional study was carried out useing data from the AZAR cohort study (ACS), which was conducted in Shabestar, Iran, from October ۲۰۱۴ to January ۲۰۱۷. Among ۱۵,۰۰۶ participants, fundamental data for ۸,۲۹۰ women were extracted, of whom ۳,۴۹۱ were in menopausal period. Data were collected using a structured and pre-designed questionnaire. To identify the prevalence of POI and associated factors, univariable and multivariable logistic regression were used.Results: This study found that the prevalence of POI, early menopause, and age at natural menopause was ۶.۱%, ۲۷.۶%, and ۶۶.۳%, respectively. Multivariable logistic regression results, after adjusting for all potential confounding factors, revealed that the odds of POI were significantly lower in women with parity ≥ ۳, overweight women, and women with late menarche. The odds of POI were also considerably higher in smokers. The results also revealed that underweight women had more than ۴ times higher odds of early menopause. Conclusion: The results revealed that parity, age at menarche, overweight, and smoking had a statistically significant relationship with POI. Due to the increasing prevalence of POI and early menopause, screening to identify the associated factors by healthcare providers will help to provide early interventions.

کلیدواژه ها:

Primary Ovarian Failure ، Early menopause ، Age at menopause ، AZAR cohort study