Clinical and biochemical alterations in Afshari sheep naturally infected with piroplasm parasites

Piroplasmosis, caused by Theileria and Babesia species, is a major tick-borne disease affecting sheep health and productivity in Iran. This study evaluated alterations in the lipid profile, fat-soluble vitamins, and hematological and hepatic parameters of Afshari sheep naturally infected with piroplasm parasites. A cross-sectional survey was conducted in ۲۰۲۴ on ۴۸ Afshari sheep from Kerman, Quchan, and Birjand regions. Animals showing clinical signs consistent with theileriosis or babesiosis and confirmed microscopically by Giemsa-stained blood smears were included. Blood samples were collected from the jugular vein for hematological and biochemical analysis. Complete blood counts, liver enzyme activities, lipid profiles, and concentrations of vitamins A, E, and K were determined. Data were analyzed using SPSS and R software, with significance set at p<۰.۰۵. Among the examined animals, ۲۶ were infected and ۲۲ served as uninfected controls. Infected sheep showed significant reductions in hematological indices (RBC, Hb, and WBC counts), total protein, triglycerides, and fat-soluble vitamin levels, accompanied by elevated liver enzyme activities (p<۰.۰۵). These alterations indicate anemia, hepatic dysfunction, and metabolic disturbances associated with piroplasmosis. Routine monitoring of liver enzymes and biochemical markers is recommended for early detection and management of infection in sheep flocks.

کلیدواژه ها:

Afshari sheep ، piroplasmosis ، hematology ، lipid profile ، liver enzymes