Cardiopulmonary resuscitation (CPR) is one of the most critical emergency medical interventions, and its success depends not only on technical skills but also on strict adherence to clinical guidelines for post–cardiac arrest care. However, previous studies have shown that gaps may exist in both awareness and clinical practice of these guidelines among specialists and residents, which can negatively affect the quality of care and patient outcomes. This cross‑sectional analytical study aimed to assess the level of awareness and practice regarding post‑cardiac arrest care clinical guidelines among specialists and residents working at teaching hospitals affiliated with Guilan University of Medical Sciences. Data were collected using a structured self-administered questionnaire to assess awareness and self-reported practice regarding post-CPR care guidelines. The study population included specialists and residents in anesthesiology, cardiology, neurology, and emergency medicine, who were selected using simple random sampling. Data analysis was performed using SPSS version ۲۷, applying descriptive statistics, Mann–Whitney U, Kruskal–Wallis, Spearman correlation, and multiple linear regression. The mean age of participants was ۳۶.۱ ± ۷.۵ years, and the majority were female (۵۸.۷%), married (۵۶.۵%), residents (۶۹.۶%), and working in neurology and emergency medicine departments (۶۰.۹%). The mean awareness score among specialists and residents was moderate (mean score: ۱۱.۰۹ ± ۱.۹۶), whereas the mean self-reported practice score was poor (mean score: ۴.۲۴ ± ۱.۹۰). No statistically significant association was observed between awareness and self-reported practice (P ≥ ۰.۰۵). However, awareness scores were significantly associated with level of education and specialty, and self-reported practice scores were significantly associated with specialty (P < ۰.۰۵). Although awareness was moderate, self-reported practice was suboptimal, highlighting the need for educational and practical interventions. These findings suggest that improving knowledge alone is insufficient to enhance clinical performance and highlight the need for targeted educational programs, practical training, and improved access to clinical resources to bridge the gap between awareness and self-reported practice.Cardiopulmonary resuscitation (CPR) is one of the most critical emergency medical interventions, and its success depends not only on technical skills but also on strict adherence to clinical guidelines for post–cardiac arrest care. However, previous studies have shown that gaps may exist in both awareness and clinical practice of these guidelines among specialists and residents, which can negatively affect the quality of care and patient outcomes. This cross‑sectional analytical study aimed to assess the level of awareness and practice regarding post‑cardiac arrest care clinical guidelines among specialists and residents working at teaching hospitals affiliated with Guilan University of Medical Sciences. Data were collected using a structured self-administered questionnaire to assess awareness and self-reported practice regarding post-CPR care guidelines. The study population included specialists and residents in anesthesiology, cardiology, neurology, and emergency medicine, who were selected using simple random sampling. Data analysis was performed using SPSS version ۲۷, applying descriptive statistics, Mann–Whitney U, Kruskal–Wallis, Spearman correlation, and multiple linear regression. The mean age of participants was ۳۶.۱ ± ۷.۵ years, and the majority were female (۵۸.۷%), married (۵۶.۵%), residents (۶۹.۶%), and working in neurology and emergency medicine departments (۶۰.۹%). The mean awareness score among specialists and residents was moderate (mean score: ۱۱.۰۹ ± ۱.۹۶), whereas the mean self-reported practice score was poor (mean score: ۴.۲۴ ± ۱.۹۰). No statistically significant association was observed between awareness and self-reported practice (P ≥ ۰.۰۵). However, awareness scores were significantly associated with level of education and specialty, and self-reported practice scores were significantly associated with specialty (P < ۰.۰۵). Although awareness was moderate, self-reported practice was suboptimal, highlighting the need for educational and practical interventions. These findings suggest that improving knowledge alone is insufficient to enhance clinical performance and highlight the need for targeted educational programs, practical training, and improved access to clinical resources to bridge the gap between awareness and self-reported practice.